OPs irreversibly inhibit acetylcholinesterase (AChE), the enzyme that breaks down the neurotransmitter acetylcholine (ACh). Organophosphates (OPs) are commonly used as pesticides and as military nerve agents including sarin, soman, tabun, and VX. Last revised: November 2011 Summary of clinical and non-clinical studies Product label: ATIVAN (lorazeapm) injection The intensity of action is directly related to the degree of benzodiazepine receptor occupancy. The pharmacodynamic consequences of benzodiazepine agonist actions include antianxiety effects, sedation, and reduction of seizure activity. Attachment to the specific binding site enhances the affinity of GABA for its receptor site on the same receptor complex. Lorazepam exhibits relatively high and specific affinity for its recognition site but does not displace GABA. This interaction is presumed to be responsible for lorazepam's mechanism of action. Lorazepam interacts with the γ-aminobutyric acid (GABA)-benzodiazepine receptor complex, which is widespread in the brain of humans as well as other species. Evidence-based medicine for Chemical Defense - including efficacy and safety A. Lorazepam has been shown to be effective as anticonvulsant against nerve agents such as sarin (GB), soman (GD), cyclosarin (GF), tabun (GA), VX, and organophosphorus pesticides. Chemical Defense therapeutic area(s) - including key possible uses Name of Chemical Defense therapeutic agent/device
0 kommentar(er)
